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Additionally, the presence of poloxamer 407 on 8314 MAb/BCNU-SLNs induced cytotoxicity in RAW264.7 cells and impeded phagocytosis by these cells

The MPC moiety, acting as an ACh analog, binds specifically to ACh receptors abundantly expressed in brain microvascular endothelial cells and neurons, enabling the S/Ce-PABMS to efficiently cross the BBB and accumulate in target neurons (Fig

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This marked it as the first dual GLP-1 and GIP receptor agonist for this purpose

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