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The ability of glutamate to improve intestinal barrier function is also demonstrated in a study using adult human IEC lines, where glutamate addition significantly reduced phorbol-induced hyperpermeability (133)

Interestingly, clinical studies show that CYP2D6 (and CYP2E1) is also expressed in the brain and is upregulated in people with AUD (137, 278)

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In patients with thyroid disorders, samples were collected twice at baseline and after 3 months of therapy