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A phase 3 study (NCT04822181), which enrolled 1200 patients with biopsy-proven MASH and fibrosis, is currently ongoing to assess the benefit of OW subcutaneous semaglutide 2 mg in this setting 93

As an analog of endogenous amylin, it is studied for its receptor-mediated signaling dynamics, sustained activation profile, and downstream neuroendocrine cascades within controlled laboratory environments

Jcker M, Gnther A, Gradl G, Fonatsch C, Krueger G, Diehl V, et al

A cell-culture study, animal model, biochemical assay, or tissue-based experiment may require different controls and endpoints

Federation of Jewish Communities of the CIS

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