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Several studies indicate that tumor cell metabolic reprogramming is governed by both inherent genetic alterations, such as the loss of tumor suppressors or the activation of oncogenes, and external influences from the tumor microenvironment, such as hypoxia, ROS, and other factors [49,50,51,52]

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Specific areas for further investigation include manipulating the activity of enzymes involved in SA and JA biosynthesis, such as ICS1 (for SA) and AOC (for JA), which may result in crops with higher resistance to specific stressors