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The EVs loaded with COL1A1 mRNA was intradermally delivered to mice with collagen depleted dermal tissue via microneedle arrays

The treatment is usually painless and the duration of the session can vary between 20-60 minutes

The volumes are larger, the tick marks are easier to hit, and the margin for error shrinks dramatically

Chin J Inform Trad Chin Med 14:2223 Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A, Mancuso M, Siciliano G (2018) Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation

Side effects are uncommon but may include mild discomfort at the injection site

These injections are beneficial for those who struggle with absorption issues, have dietary restrictions, or seek an energy or immunity boost