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Additionally, preclinical research suggests potential applications in treating chronic conditions, including inflammatory bowel disease and fibrotic disorders

However, in agreement with our detected concentrations by HF-LPME, previous measured whole-body concentrations of weakly acidic sulfonamides and weakly basic diphenhydramine in fish significantly increased with increases in the neutral molecule forms 31,32 , suggesting that the acceptor concentration in HF-LPME can be used as a surrogate for the internal concentration in D

With the wide range of C18-based columns and tips available commercially, this approach can be applied to any sample amount

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