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Timeline for Pain Relief (48-72 Hours) Most people see a big improvement in 48 to 72 hours

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Before we address treatment options, however, it is important to understand a few basics about knee pain: the most common form of knee pain is due to an underlying condition called osteoarthritis (OA), also known as degenerative joint disease. In a normal, healthy knee joint, there is a smooth, outer surface lining covering the surface of the bones in the knee joint (called the cartilage and synovial membrane) that protects, lubricates, and cushions the bones of the knee joint to allow smooth joint movements as you bend and straighten your knee