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doi: 10.3389/fmolb.2022.964624 Received 08 June 2022 Accepted 11 July 2022 Published 26 August 2022 Volume 9 - 2022 Edited by Giuseppe Calamita, University of Bari Aldo Moro, Italy Reviewed by Umberto Laforenza, University of Pavia, Italy Paul Yancey, Whitman College, United States Updates Copyright 2022 Ilyas, Wijayasinghe, Khan, El Samaloty, Adnan, Dar, Poddar, Singh, Sharma and Khan

In some patients with somnolence (approximately one-half), there was associated reduced nutritional intake and weight loss

The overall fold of the L701H/T877A double-mutant AR LBD complexed with 9-fluorocortisol (PDB: 1GS4) is similar to previous agonist structures

J Inherit Metab Dis (2015) 38(2):23142

This mutation does not affect the amino acid sequence, but does alter mRNA splicing in favor of transcripts lacking exon 7 [12][17]

Additional funding was subsequently applied for some aspects of this research from NIH R01DK-53069, NIH R21DK-070003, Department of Defense PR064756, and NIH G12RR-03026