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25 (1), e133e8 (2015)

This multi-pathway activity resembles what we see with other biologic treatments in orthopedic surgery, where the therapeutic effect comes from coordinated biological response rather than a single drug-receptor interaction

Manganese has a role in Protein metabolism, disease resistance, bone, cartilage and connective tissue development, reproduction/fertility, ovulation, spermatogenesis, and embryo survival