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In the fatty acid pathway, the accumulation of LCACs is thought to be a major factor in ROS production

10.1016/j.nbd.2020.104786 3 AnjaneyuluJ.RV.GodboleA

When administered to laboratory rat models, CH 2 O caused kidney volume, glomerular volume, the number of glomeruli to reduce, and blood creatinine and urea to increase

Arciniegas A, Amaya LE

Together, this work uncovers a vital functional role for Hb in T-lymphocytes, and may have implications for hemoglobinopathies

J Med Chem 60:67216732 Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, Da-Fonseca PC, Winzeler EA, Ng CL, Bogyo M, Fidock DA (2019) Covalent Plasmodium falciparum -selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents