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You should contact your healthcare provider promptly if you experience any of the following: Severe or worsening abdominal pain Bloating that does not improve after 2-3 weeks Significant distress or interference with daily activities Signs of dehydration, such as dizziness, dark urine, or reduced urination Signs of a possible allergic reaction (rash, swelling of face/throat, difficulty breathing) Bloating accompanied by persistent vomiting or inability to keep fluids down Long-term outlook The majority of patients find that bloating eases within 48 weeks as their bodies get used to the medication

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William Castle demonstrated that gastric juice contained an "intrinsic factor" which when combined with meat ingestion resulted in absorption of the vitamin in this condition

Rare allergic reactions, particularly in individuals with sensitivities to specific additives