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histidine metabolism

Lancet 390 , 15111520 (2017)

however, persistent or dysregulated activation can drive neurodegeneration through inflammatory signaling, metabolic imbalance and synaptic disruption

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Dietary intake was recorded over two consecutive days, and the average of these two daily records was used to represent each participants dietary intake, aiming to more accurately reflect their habitual diet

This modification can neutralize the positive charge of lysine, affecting protein-protein interactions and stability [50]