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It can furthermore promote Nrf2 activity by suppressing keap1 [122]

2007;7(Suppl

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SCFAs exert their regulatory functions mainly through the inhibition of HDACs and the activation of Gpr43 and Gpr109a, and intervene in the key factors of kidney and brain through the mechanism of renalintestinal axis and brainintestinal axis, which not only control inflammation to regulate blood pressure, but also influence metabolism and immunity to regulate blood pressure

Proc Natl Acad Sci U S A 95:29562960 Wachter A, Wolf S, Steininger H, Bogs J, Rausch T (2005a) Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae

To capture global transcriptomic changes associated with distinct ECM environments and to identify gene signatures linked to MC differentiation, plasticity, and other relevant pathways, we analyzed the expression of MITF target genes, MC-specific genes, and broader signaling networks that are associated with the phenotypic shifts observed across ECM conditions