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They appear together on clinic menus, in wellness stacks, on podcasts

B12 may lower homocysteine levels which could contribute to a lower odds of heart disease, but only in people who have a diagnosed B12 deficiency, Swenor says

Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

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But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

Safety Considerations B12 shots are generally considered safe for most individuals