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The p -value indicates that the dispersion is not due to random error, but in fact, it is due to real differences in the study effects (Figure 3)

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Most studies are small-scale, lack robust methodology, or have not been replicated in larger populations

Indeed, the suppression of KEAP1, the NRF2 inhibitor, enhances survival and synaptic performance, whereas the overexpression of NRF2 improves sleep patterns by reducing oxidative stress (Spiers et al