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Im not saying they dont work, and I also dont suggest that you stop anything cold-turkey. We know that these drugs all lower a laboratory biomarker called TNF-alpha

About 75% of the microbiome is made up of the two main taxa Bacteroidetes and Firmicutes (45), and Proteobacteria, Actinobacteria, Fusobacteria , and Verrucomicrobia are found in comparatively small amounts (46)

Caution: These are anecdotal and not peer-reviewed

Leukocyte positioning depends on chemokines on the endothelial surface and cognate chemokine receptors on marginalized leukocytes

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a diabetes mellitus comprehensive care plan2022 update

It's the form supported by the largest body of research, it's exceptionally stable in storage, which matters for consistent potency across batches, and it's the form most clinics and pharmacies use as a result