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Acylcarnitines are transported across the inner mitochondrial membrane by the Carnitine/Acylcarnitine Carrier (CAC) in exchange for free carnitine

Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E: Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits ExtracellularAspergillus fumigatusHyphal Growth and Corneal Infection .J Immunol2016, 196:336-344 57

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Figure 1 2.3 Oxidative stress-mediated reproductive dysfunction Excessive accumulation of ROS disrupts reproductive function by impairing gamete integrity, altering hormonal signaling, and promoting chronic inflammation (6567)

Dietary carcinogens and anticarcinogens

However, heart mitochondria isolated from these animals show severe dysfunction, i.e., inhibition of mitochondrial Complex I and respiration with NAD + -linked substrates, inhibition of aconitase, and increased sensitivity to Ca 2+ [113]