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(2R,6R)-hydroxynorketamine promotes dendrite outgrowth in human inducible pluripotent stem cell-derived neurons through AMPA receptor with timing and exposure compatible with ketamine infusion pharmacokinetics in humans

what increased most was the trough (basal) GH level between pulses

It includes 25P/28P/29P mutations to reduce the proteins propensity to form fibrils and -sheets and the insertion of a C-terminal proline improves binding to the CTR channel