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In particular, mechanism-based inactivation (MBI) often involves metabolic bioactivation of natural products by drug metabolizing enzyme to an electrophilic reactive intermediate, which covalently modifies an active site amino acid residue and/or coordinates to the heme prosthetic group, and leads to quasi-irreversible or irreversible inactivation (Zhang et al., 2020b)

Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease

It can be used as a curative measure, both by itself and in combination with other treatments such as radiotherapy or surgery (both pre and post), as well as for palliative treatment

Selective induction of endogenous NQO1 was seen in metabolically relevant target tissues of Keap1 -KO mice including skeletal muscle, liver, and WAT while expression of other Nrf2 targets such as the antioxidants GCLC, HO-1 and SOD2 was minimally impacted

Finally, we highlight potential treatments that target cerebral metabolism, such as nutraceuticals, ketone bodies and dietary interventions

Mundil, D., Cameron-Vendrig, A