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Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice

I.UthirapathyS.BallalS.GabbleB

Ford AC, Quigley EMM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al

Proteins were reduced with 5 mM dithiothreitol (Sigma-Aldrich) for 1 h at RT and alkylated with 10 mM iodoacetamide (Sigma-Aldrich) in the dark for an additional 45 min at RT

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In contrast, natural products have attracted increasing attention as promising candidates owing to their multitarget regulatory properties, relatively low toxicity, and ability to modulate the tumor microenvironment