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FASEB J 17(1):6769

Davidson et al., 1977

This trauma extends beyond hair cells, impacting supporting cells essential for cochlear architecture and function, thereby jeopardizing the structural integrity of the auditory system

Following the above general procedure F, A and B respectively and starting from the commercially available 4-chloro-3-nitrobenzoic acid (Scheme 4), the crude reaction mixture was purified by column chromatography (dichloromethane:methanol=40:1) to provide the desired tert-butyl 3-amino-4-(2-adamantylamino)-benzoate (SRS16-82, Scheme 4) (700 mg, 2.046 mmol, 88% (3 steps)

If you have been diagnosed with B12 deficiency, are taking metformin, or have recently been told your HbA1c result is unexpectedly low or inconsistent with your symptoms, it is worth raising this with your GP

Both leucovorin and folic acid can be transformed by different enzymes into 5-methyl-tetrahydro-folate, which efficiently crosses the BBB using the folate receptor alpha (FR) transporter, and is thought to be the main active folate in the CNS 99,100