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Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice

10.1016/j.ajpath.2013.01.051 40 MeinhardtM

While mitochondrial-targeting motifs such as TPP can increase delivery efficiency, 554 off-target effects from nonspecific uptake necessitate optimization through dual-targeting strategies, such as hybrid nanoparticle-hydrogel systems

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DIRECTION FOR USE: Oral Administration

For the free copper ions to be detectable, the intracellular concentration would need to increase by nine orders of magnitude, which would result in approximately one unbound copper atom per cell [13, 15]