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10.3389/fphar.2022.966645 135 WangY.YouK.YouY.LiQ.FengG.NiJ.et al (2022d)

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Fatigue can be categorized as chronic when it persists for more than 6 months and is unrelieved by rest, often without a clear underlying medical cause

Moreover, the authors highlighted phenoconversionthe modulation of metabolic activity by external factors such as drug-drug interactionsas a critical complicating variable