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While even extremely high doses of GHK-Cu are unlikely to cause any adverse reactions, Pickart has estimated that the peptide can produce toxic action and start lowering a subjects blood pressure starting from an astronomical dose of about 22,500mg [13]

In STAT3-knockdown MCECs (siSTAT3-transfected), GHK-Cu failed to enhance wound healing in scratch assays (Figures 7A,B) and did not upregulate ZO-1/Occludin expression (Figures 7CF)

New England Journal of Medicine (2025) 2

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