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Notably, metabolites such as AGEs, dysregulated ketone bodies, and BCAAs have been demonstrated to be directly or indirectly associated with structural abnormalities and functional decline in the lung (e.g., impaired surfactant synthesis, diminished respiratory muscle function)

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[DOI] [PubMed] [Google Scholar] 91.Dopkins N., Miranda K., Wilson K., Holloman B.L., Nagarkatti P., Nagarkatti M

Although we did not measure the ROS level directly, the above-described changes in SOD1 may suggest that the M-CFSs of both mushrooms have antioxidant properties in the HT-22 cell line

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There is substantial evidence indicating the involvement of ROS in the pathophysiology of AD