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Similar content being viewed by others Introduction Several energy-saving adaptations are triggered by the hypothalamus during food deprivation, including increases in skeletal muscle work efficiency, and inhibition of thermogenesis, thyroid and reproductive axes 1,2,3,4,5,6,7

If any step of the process is disrupted, the activity of GPX4 will decrease, resulting in the accumulation of intracellular peroxides, which contributes to ferroptosis

Interestingly, the overall levels of nucleotides, CTP and TTP were significantly increased, up to 3-fold in HIF1 KO cells, in line with enhanced synthesis (Fig