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The majority of subjects were male (64.95%) and had inflammatory bowel disease (IBD) (78.62%)

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature Chemical Biology, vol

Vincristine, a chemotherapeutic agent, is known to cause neurotoxicity by decreasing levels of the antioxidant protein Nrf2 and its downstream targets HO-1 and NQO1

doi: 10.1016/j.psychres.2018.05.059 203 BazinetRPLayS

The pathological process of IDD is a vicious circle (Figure 2)

For established cognitive support, the evidence-based options include aerobic exercise (strong evidence for cognitive benefits, especially executive function and processing speed), sleep optimization (critical for cognitive function), Mediterranean diet (modest evidence for cognitive protection over years), treating sleep apnea (significant cognitive improvements when this condition is addressed), treating depression (major cognitive effects when present), donepezil and other approved Alzheimer drugs (modest evidence-based effects in actual Alzheimer disease), and stimulants (well-established for ADHD)