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Phase 2 detoxification does a bunch of chemistry, like sulfation and methylation, that neutralizes the intermediary toxins, rendering them non-toxic

THYROID REFRACTORINESS IN AN ATHYREOTIC CRETIN FED SOYBEAN FORMULA (1965) N Engl J Med 273:8387

The ability of the blood-brain barrier to absorb Se-NPs which maintain a healthy microenvironment is essential for brain homeostasis

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Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge J, Sleddens-Linkels E, Hoeijmakers JH, et al