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Furthermore, the use of recreational drugs and alcohol, particularly marijuana and alcohol, can contribute to its development

DOI: 10.1016/S0140-6736(16)30378-6

A loss of CFTR and -catenin resulted in increased NF-B expression in mutated organoids, but this did not result in the expected ductular reaction

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Whilst the potential benefits are substantial, these studies highlight the need to select platinum combinations for investigation in appropriate disease settings and patient populations to attain clinical benefit