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References Knezevic NN, Candido KD, Vlaeyen JWS, Van Zundert J, Cohen SP

Vitiligo and hashimotos thyroiditis: Autoimmune diseases linked by clinical presentation, biochemical commonality, and autoimmune/oxidative stress-mediated toxicity pathogenesis

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

10.15252/embj.201899259 EMBO J

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Its action is to extend and laterally deviate the wrist