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Reduction in proteasome functionality may lead to the accumulation of toxic protein, which can be detrimental to cardiac tissues [5]

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The transcription factor can then translocate into the nucleus where it dimerizes with one of the small musculoaponeurotic fibrosarcoma (sMAF) proteins and binds to the antioxidant response element (ARE), or Maf protein recognition element (MARE), to promote expression of various cytoprotective and antioxidant genes, including HMOX1, NQO1 and SOD (52, 55)

Fu L, Wang C, Wang J, Ni S, Wang Y (2019) Maillard reaction with ribose, galacto-oligosaccharide or chitosan-oligosaccharide reduced the allergenicity of shrimp tropomyosin by inducing conformational changes

These phylogenetically-conserved mechanisms are reported to play central roles in metabolic, transcriptional and neuronal networks 12,34,35,36,37,38,39,40