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This sudden toxin overload triggers an immune response, causing an intensification of symptoms

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CPAP therapy can be cumbersome and uncomfortable, so recommendations for CPAP are generally reserved for patients who experience excessive daytime sleepiness, those with comorbid hypertension, and those for whom their sleep disruption affects their quality of life

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Primary endpoints and endpoint adjudication The primary endpoint of the PRECISIONS trial will be the time to a composite of 10% relative FVC decline, first respiratory hospitalization, lung transplantation, or all-cause mortality

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