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Beyond the toxic gain-of-function effects of mHTT, HD pathogenesis involves a range of interconnected mechanisms, including mitochondrial dysfunction, transcriptional dysregulation, impaired autophagy, proteostasis failure, excitotoxicity, oxidative stress, and chronic neuroinflammation [3843]

These experiments suggest that Epithalon may be useful in exploring mechanisms of photoreceptor preservation, retinal signaling, and neuroprotective strategies in the eye

Remarkably, Western blot data showed increased protein level of LRP-1 and decreased protein level of P-gp in the isolated capillaries of the striatum of Thy1-Syn mice [257]

One explanation for this may be their functional redundancy shared with certain PRXs

The focus is on Functional Health and personalized nutrient therapynot just hydration

These effects can reduce food intake and increase energy expenditure, leading to weight loss