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Crucially, no signal of cardiac toxicity, cytokine release syndrome, or treatment-related ILD was observed, and no adverse events led to treatment discontinuation or death, supporting the clinical tolerability of JSKN016 within the studied dose range [101]

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Keratinocytes were proven to be sensitive to ferroptosis and the expression of multiple pro-inflammatory cytokines is upregulated

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Hsu-Liang Hsieh, National Taiwan University, Taiwan