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Severe multisystem symptoms require specialist evaluation Seizures, metabolic strokes, severe weakness, cardiomyopathy, developmental regression, exercise-induced rhabdomyolysis, lactic acidosis, major hearing or vision loss and strong maternal inheritance patterns may require neurological, metabolic or genetic evaluation

and (2) it enables the active biosynthetic functions of regeneration, such as the production of metabolic substrates for axons and the assembly of new myelin, by sustaining glycolytic and mitochondrial flux

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