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Microenvironmental regulation of tumor progression and therapeutic response in brain metastasis

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This 90-day randomized controlled trial (n=32) systematically evaluated the effects of Wuwei Jianpi San (WJPS), a traditional Chinese herbal formulation, on growth performance, immune function, gut microbiota, and bile acid metabolism in yaks, which is the first systematic association between the traditional Chinese medicine compound WJPS and the multi omics characteristics of yak intestines, aiming to address these challenges

Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects

D., Koyuturk, M

Late stage PD is characterised by an increasing burden of drug refractory motor and non-motor symptoms with limited efficacy of available treatment options highlighting the pressing need for disease-modifying therapies