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3- Clinical uses and practicality: HGH has been proven for GH deficiency, short-term gains in lean mass/fat loss, but needs strict indication because of safety/monitoring needs

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

Jones 3 , Bolin Niu 4 , George Therapondos 5 , Mae Thamer 6 , Onkar Kshirsagar 6 , Yi Zhang 6 , Paulo Pinheiro 7 , Ronnie Fass 8 , Mandana Khalili 9 and Amit G

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This work shows that in CRC the emergence of DTP cells may be associated with transdifferentiation, as has been observed in other tumour types