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ProTox-II incorporates the prediction of the various toxicities of the chemical which can be measured qualitatively as binary (active or inactive) in terms of endpoints such as acute toxicity, hepatotoxicity, carcinogenicity, immunotoxicity, mutagenicity, cytotoxicity, adverse outcome (toxicology in the twenty-first century) pathways, and toxicity targets 39

Instead, more modest changes occur at the adenosine binding pocket in Sas Pcob culminating with the formation of a water/hydroxide ligated Co(III)balamin

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