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However, the peptide characteristics that enable absorption through the gastric mucosa, including its stability in acidic environments and resistance to enzymatic degradation, suggest it should maintain activity when absorbed through nasal mucosa as well

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doi:10.1016/j.phymed.2012.07.009

The engineering problem, then, was to preserve oxyntomodulins balanced dual activity while giving it a half-life compatible with convenient dosing

It is also explored for mitigating damage from nonsteroidal anti-inflammatory drugs

controlled human efficacy evidence is lacking and individual results vary