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NAC reduces oxidative levels but may impair antitumor immune responses mediated by ICD in certain contexts [264]

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In addition, changes in serine levels show potential in distinguishing low-grade (Gleason score 6) from high-grade (Gleason score 7) prostate cancer, with more pronounced abnormalities in serine metabolism observed in high-grade tumors (83, 84)

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While sibling controls reduce genetic and familial confounding, they cannot replicate the certainty of a randomized controlled trial