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Liver enzyme elevations (ALT and AST above 3 times the upper limit of normal) occurred at rates similar between orforglipron and placebo groups, with no dose-dependent pattern suggesting drug-related hepatotoxicity

doi: 10.1126/science.270.5234.296

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Elemental mapping of toxicants in motor neurons from people with ALS is impractical because of the widespread loss of these neurons by the time of autopsy

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