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The main chain of G57 on TM1a forms a hydrogen bond with S402 on TM8, while G57 in TM1a of the inward-open conformation swing away from the central pocket, resulting in an open pathway from the central pocket to the cytoplasm (Fig

Reported Effects Neuroprotection (preclinical): HNG protected neurons from amyloid-beta and other Alzheimers-relevant insults in vitro by preventing mitochondrial dysfunction and apoptosis [3]

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