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Its action facilitates the oxidation of glucose 6-phosphate, a cyclic hemiacetal with C-1 in the aldehyde oxidation state, into a cyclic ester, specifically a lactone

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Association of insulin resistance with depression severity and remission status: defining a metabolic endophenotype of depression

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The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides