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We also demonstrated that this complete Ube3a deletion in MEFs affected the proliferation and apoptosis capacity of these cells [29, 30]

They may exert moderate effects on several pathways rather than a blockbuster effect on one

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However, the same group reported decreased QA-immunoreactive microglia in the hippocampus, suggesting that QA expression in the brain may be region-specific or that hippocampal cell atrophy may have hindered its detection [63]