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Proprietary delivery systems aim to increase systemic exposure

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The delta fluorescence intensity (F) was calculated as fluorescence intensity of assay wells containing pre-reaction mixture and H 2 O 2 without PRDX1 and compounds (F blank ) minus the fluorescence intensity of assay wells containing pre-reaction mixture, H 2 O 2 and PRDX1 incubation with or without compounds (F PRDX1+compound , or F PRDX1-compound ), which reflects H 2 O 2 consumption of each well (F=F blank F PRDX1+compound, or F blank F PRDX1-compound )

Importantly, catecholaldehydes are capable of protein crosslinking due to their catechol and aldehyde moieties [106]