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Increased proinflammatory cytokines direct tryptophan metabolism towards the production of kynurenine, decreasing serotonin availability and generating neurotoxic metabolites (quinolinic acid)

Rat full-thickness wounds (6mm diameter, 13-day study) treated with GHK showed 64.5% reduction in wound size compared to 45.6% for vehicle-treated and 28.2% for control group, accompanied by significantly lower TNF- and elastin-degrading MMPs

47 However, despite all these shortcomings, as a model the rabbit ear vein does allow the physician to compare the mechanism of action of various sclerosing solutions both clinically and histologically