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Other studies have focused on the loss of Glu transporter function GLT-1 (EAAT2) in the context of HD

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Moreover, knockdown of HMGB1 or S1R, as well as overexpression of Sirt6, alleviates diabetic nephropathy by regulating the NRF2 pathway, indicating the potential of NRF2 as a research target [61, 128, 129]

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Consistent with these findings, other studies confirmed that NADPH was used to generate NO, which suppressed ferroptosis [48, 49]

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