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The loss of GST function may contribute to both acute and chronic illnesses (Ashfaq 2008

Metformin (Sigma-Aldrich, D150959-5G) was prepared at a concentration of 200 mg/kg and administered via intragastric administration once daily over the eight-week program

Furthermore, the mRNA level of GR was significantly increased, but GT or GPx was decreased at 24 h post-zinc ion treatment

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Further examination of this and other metabolite profiles in the setting of chronic APAP exposures is indicated to better understand the potential impact of chronic drug therapy to disease expression and/or to alterations in endogenous metabolism

Furthermore, several novel GLS inhibitors have exhibited superior therapeutic efficacy in clinical settings and preliminary studies, such as IN-3, have been shown to possess antiproliferative effects on PCa