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Gastrointestinal dysfunction in a Parkinsons disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus

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These findings highlight the value of MeDIP-seq in uncovering the epigenetic mechanisms underlying complex diseases

Mean weight reductions were greater with all cagrilintide doses (roughly 6.0% to 10.8%) than with placebo (3.0%), and the top 4.5 mg dose modestly out-performed the active comparator, once-daily liraglutide 3.0 mg (10.8% vs 9.0%)

It may influence sleep-related signaling, circadian rhythms, and stress pathways in experimental models, though findings are limited to preclinical and in vitro studies

A similar proportion of adults reported adverse events across all three groups in the study