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In good agreement, the association between an OCTN2 SNP (rs27437), down-regulating the OCTN2 expression and the CRC risk has been identified (Zou et al., 2018)

Drug Metabol Drug Interact 23:5168 Yamauchi Y, Hasegawa A, Mizutani M, Sugimoto Y (2012) Chloroplastic NADPH-dependent alkenal/one oxidoreductase contributes to the detoxification of reactive carbonyls produced under oxidative stress

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demonstrated a physical interaction between glutamine-induced MKP-1 and pcPLA2, suggesting that glutamine can directly deactivate cPLA2 via early induction of MKP-1 [81]

To study the joint linear relationship of different variables with oxidative stress variables, complementing the correlation analysis, a multiple linear regression model was performed for each oxidative stress variable in R

Birch M, Sibley G